Quinolones are contraindicated if a patient has epilepsy, QT Prolongation, pre-existing CNS lesions, central nervous system inflammation or those who have suffered a stroke. There are safety concerns of fluoroquinolone use during pregnancy and as a result are contraindicated except for when no other safe alternative antibiotic exists.
They are also contraindicated in children due to the risks of damage to the muscoskeletal system.[ Their use in children is not absolutely contraindicated however. For certain severe infections where other antibiotics are not an option their use can be justified. Quinolone should also not be given to people with a known hypersensitivity to the drug.
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